What are your biggest Maintenance Issues?

When it comes to instrumentation.

Column on the LC gets contaminated

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Contamination on the Mass Spectrometer

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I feel you here! We have gotten some R&D samples that were so contaminated with pesticides (that are already known to stay in the column and contaminate the detector) that we had to dilute it soooo much and then clean the instrument to ensure no contamination went to the other samples. We had to rerun all of the samples on that batch that ran afterward since there was so much carryover. It was like they dipped the concentrate in straight pesticides!